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The study found that COVID-19 patients recovered rapidly and maintained antibodies



COVID-19, coronavirus

SARS-CoV-2 (shown here in electron microscope image). Source: National Institute of Allergy and Infectious Diseases, NIH

One of the pressing questions about COVID-1

9 remains: How long does immunity last? An important indicator of immunity is the presence of virus-specific antibodies. Previous studies have produced conflicting documents about whether people who have recovered from the infection can maintain protective antibodies. A new study led by investigators from Women’s Hospitals and Brigham examined blood and cell samples from patients who had mild to moderate COVID-19 recovery and found that while the Antiviral antibodies are decreased in most individuals after resolving the disease, and a small number of patients still maintain antiviral antibodies that produce antibodies several months after infection. These antibody ‘maintainers’ have a shorter symptom episode, suggesting that some individuals recover from COVID-19 faster may induce a more effective and sustained immune response to the virus. . Results are published in UMBRELLA.

“We have found a small group of individuals that heal quickly,” said Duane Wesemann, MD, Ph.D., an immunologist and associate doctor at the Department of Clinical Allergy and Immunology. while maintaining the level of antibody specific to the virus after COVID-19. and is an associate professor at Harvard Medical School. “The type of immune response we’re seeing in these people is like investing in an insurance policy – that’s how the immune system adds a potential defense against viral encounters in the world. future.”

The Wesemann Laboratory studies the entire set of antibodies the host’s immune system produces and how they learn to recognize the pathogen. In the spring of 2020, the team turned their attention to the COVID-19 pandemic and the immune responses of infected people. They are eager to understand the nature of the antibody response to viruses. To achieve this goal, the team recruited and enrolled 92 people in the Boston area who had recovered from COVID-19 between March and June 2020. Five were hospitalized but all were hospitalized. others have recovered at home. The research team collected and analyzed monthly blood samples, measuring a wide range of antibodies, including immunoglobulin-G (IgG), against the virus that causes COVID-19. They divided the cohort into two groups – the group that maintained viral-specific IgG levels for several weeks and the group lost them. The team analyzed these groups and the potential connections they have with other clinical and immunological data.

The research team found that anti-viral IgG levels tended to decrease significantly in most individuals over a period of three to four months. However, in about 20 percent of individuals, antibody production remains stable or enhances at about the same time. The team found that these “maintainers” had symptoms for a significantly shorter period of time than “decomposers” (an average of 10 days versus 16 days). Sustainable developers also differ in populations of memory T cells and B cells, two types of immune cells that may play a key role in immune defense and memory.

“The data points to a type of immune response that is not only proficient in dealing with viral disease by quickly addressing symptoms, but also producing better cells that can commit,” Wesemann said. produce more permanent anti-viral IgG antibodies. “Finding out how these individuals could support longer-term production of COVID-19-related antibodies will also be important to our understanding of the immune system in general.” . ”


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More information:
Yuezhou Chen et al, Quick COVID-19 Healers Maintain production of Anti-SARS-CoV-2 antibodies, UMBRELLA (Year 2020). DOI: 10.1016 / j.cell.2020.10.051

Magazine information:
UMBRELLA

Provided by Brigham and Women’s Hospital

Quote: The study found a subset of COVID-19 patients with rapid recovery and maintenance of antibodies (2020, November 3) retrieved November 4, 2020 from https://medicalxpress.com / news / 2020-11-uncovers-subset-covid-patients-recover. html

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