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Scientists create hybrid tissue structures to regenerate cartilage



WFIRM scientists create the hybrid tissue structure to regenerate cartilage

A highly resilient hybrid structure for cartilage fiber regeneration is created by creating a cell-filled gellan / fibrinogen synthetic gellan bio-bond along with a fibroin filament methacrylate bio-bond in a model. cross alternating. Credit: WFIRM

Scientists at the Wake Forest Institute of Regenerative Medicine (WFIRM) have developed a method of biologically printing a type of cartilage that can help restore function of the knee damaged by arthritis or trauma.


This cartilage, called the fibrous cartilage, helps connect the tendons, ligaments or bones and is mainly found in the meniscus cartilage in the knee. The meniscus is supple rubber cartilage that acts as a shock absorber in the knee joint. The degeneration of the meniscus affects millions of patients and laparoscopic part of the meniscus is one of the most common orthopedic surgeries performed. Besides surgery, there is a lack of treatment options available.

In this latest proof-of-concept strategy, the scientists were able to biologically print a hybrid tissue structure for cartilage regeneration by printing two specialized biological bonds ̵

1; cell-containing hydrogels – Together to create a new formula that provides a cell-friendly microcosm and structural integrity. This work is done with the Integrated Organ and Tissue Printing System, a 3-D bio-printer developed by WFIRM researchers over a 14-year period. The system deposits biodegradable, plastic-like materials to form tissue “shapes” and the biological bonds that contain cells to build new tissues and organs.

Sang Jin Lee, Ph.D, associate professor at WFIRM and the author of the recently published paper, said: “In this study, we were able to create a hybrid structure with high elasticity. for advanced cartilage fiber regeneration. Material chemistry Journal. “The results demonstrate that this bioprinted structure offers a flexible and promising alternative to the production of this tissue type.”

For the study, Lee and the WFIRM team tested different formulations and measured response to force or applied stress, rate of expansion, strength and flexibility of the material. One provides the proper cellular micro-environment to sustain cells and help them grow while the other bio-link offers excellent bio-mechanical behavior and structural integrity. The final formula of the two bio bonds used is to co-print each layer to create a mesh-like model. The structures were implanted into a small animal model for observation for 10 weeks and evaluated at intermittent intervals, showing consistent function.

James Yoo, MD, Ph.D., professor at WFIRM said: “A larger pre-clinical study will be needed to further examine the body’s response and joint function recovery using the This regenerative drug treatment.

“We have a need for effective treatments and therapies to help patients cope with degenerative joint problems, especially knees,” said Anthony Atala, MD, director of WFIRM. “This proof-of-concept study helps point our work in the right direction so that one day we can make this vital tissue that is so important to this patient.”


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More information:
João B. Costa et al, High elastic 3D bio-hybrid structure for advanced cartilage fiber tissue regeneration, Material chemistry (Year 2020). DOI: 10.1021 / acs.chemmater.0c03556

Provided by Wake Forest University Baptist Medical Center

Quote: Scientists create hybrid tissue structures for cartilage regeneration (2020, November 9) retrieved November 9, 2020 from https://phys.org/news/2020-11-scientists- hybrid-tissue-cartilage-regeneration.html

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