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Researchers found autoantibodies behind coronavirus coagulation



A new study shows that doctors have found the culprit causing severe clotting phenomenon in half of coronavirus patients hospitalized.

Researchers at Michigan Medicine studied blood samples from 172 COVID-19 patients hospitalized to look for eight types of autoimmune antibodies that cause blood clotting. Autoimmune disease refers to when the immune system mistakenly attacks healthy cells, according to Johns Hopkins Medicine. The results are published on Monday in the journal Science Translational Medicine.

Blood clots are known to cause stroke.  (iStock)

Blood clots are known to cause stroke. (iStock)

“In patients with COVID-19, we continue to see a continuous cycle,” said Dr. Yogen Kanthi, co-author and assistant professor at the Frankel Medical Center of Michigan and a Lasker patient. , self-amplification of inflammation and coagulation in the body investigators at the National Heart, Lung and Blood Institute of the National Institutes of Health, said in a newsletter. “Now we know that autoantibodies could be the culprits behind the clotting cycle and inflammation that makes already struggling people even sicker.”

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These autoantibodies are thought to circulate in the bloodstream, attack cells and cause blood clots in veins, arteries and vessels, according to the report. Blood clots can lead to stroke, and earlier in pandemic reports have emerged younger coronavirus patients with blood clots have had a sudden stroke.

The autoantibodies in the study are often found in patients called antiphospholipid syndrome, an autoimmune disease, according to the news.

Dr Jason Knight, corresponding author and rheumatologist at Michigan Medicine said, “half of all patients hospitalized with COVID-19 are positive for at least one of the autoantibodies, which is quite unexpected. “.

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The study also revealed that, of the 172 patients, 19% died and 8% remained hospitalized during the analysis. In addition to the autoantibodies that cause blood clots, the researchers found that many of the patients in the study had “neutrophil cytoplasmic (NET) trapping in the blood” or “destructive white blood cells. explosion ”, which contributes to inflammation, according to the release.

“These findings suggest that half of all patients hospitalized with COVID-19 become positive for …[the] These antibodies and autoantibodies are known to cause disease [or cause disease], ”The study authors concluded.

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