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Nasal sprays may protect against COVID-19: scientists



Researchers at the University of California, San Francisco have invented a nasal spray to use synthetic antibodies, which they believe will help stop the spread of coronavirus.

According to a report on the university’s website, a research group led by graduate student Michael Schoof designed synthetic molecules that “tightly clasp the important SARS-CoV-2 apparatus that enables viruses. infects our cells ”.

An article published on the bioRxiv preprinted server said that experiments using live virus showed that the molecule was among the most powerful COVID-19 antiviral substances yet to be discovered.

According to ABC 7 News, although this is not a traditional vaccine, the researchers believe that one day spraying of a synthetic antibody, called “AeroNabs”, from a nasal spray or inhalation could protect against the insect is deadly until a vaccine becomes available, according to ABC 7 News.

“Because it̵

7;s so stable we can basically put in one of these things, this is a small nebulizer,” said Dr. Aashish Manglik, assistant professor of pharmacy chemistry at UCSF. Aashish Manglik, assistant professor of pharmacology at UCSF, who added that aerosolizing agents were first discovered in camels and similar animals, known as nano-bodies.

They are smaller than human antibodies and can be manipulated to perform specific tasks. Like attaching them to mutant proteins on coronavirus.

“It’s really a really effective mousetrap. It binds to one of these spike proteins and never leaves, ”says Manglik.

The researchers studied about 2 billion synthetic nanoparticles before they found the best candidate, which they have redesigned to be even stronger, the news agency reported.

A UCSF researcher examines a tube of pure mutant protein from the SARS-COV-2 virus in Aashish Manglik's laboratory.
A UCSF researcher examines a tube of pure mutant protein from the SARS-COV-2 virus in Aashish Manglik’s laboratory.Noah berger

Knowing that the coronavirus used its spikes to attach itself to the outside of a lung cell called the Ace2 receptor, they worked to prevent its track invasion.

When AeroNabs binds to the mutant protein, the virus is unable to bind to the receptor and thus loses the ability to infect cells, ABC 7 News reported.

“Much more effective than wearable personal protective equipment, we consider AeroNabs as a molecular form of PPE that could serve as an important deterrent until the vaccine provides a Longer Term Solution for COVID-19, ”said AeroNabs co-inventor Peter Walter, professor of biochemistry and physiology at UCSF.

For those who do not have access to or respond to the coronavirus vaccine, Walter added, AeroNabs could be a more permanent line of defense against the disease.

Manglik, who regularly uses nano-bodies in his research on the structure and function of proteins, said: “Although they function like antibodies found in the human immune system. , the nano-bodies offer several unique advantages for effective treatment against SARS-CoV-2. “

The UCSF team is in discussions with potential partners to increase production for clinical trials.

If successful, researchers aim to make AeroNabs widely available as an inexpensive over-the-counter or anti-coronavirus preventive or treatment.


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