In late 2019, the severe acute coronavirus 2 respiratory syndrome (SARS-CoV-2) emerged in China and has since triggered the Coronavirus 2019 epidemic (COVID-19). The first COVID-19 case in New York City (NYC) was officially confirmed on March 1.st The year 2020 is followed by a serious local epidemic.first To understand serum ratio dynamics, we performed retrospective cross-sectional analysis, repeating the SARS-CoV-2 spike antibodies over a weekly period from early February to July. 2020 using more than 10,000 plasma samples from patients at Mount Sinai Hospital in NYC. Here we show the dynamics of serum rates in the ‘urgent care’ (UC) group, added to COVID-19 cases during the outbreak and the ‘routine care’ (RC) group. , more closely representing the general population. Serum prevalence increased at different rates in both groups, with positive serum samples as early as mid-February, and leveling off slightly above 20% in both groups after the episode. in remission at the end of May. From May to July, the prevalence of serum remained stable, indicating long-term antibody levels in the population. Our data show that the introduction of SARS-CoV-2 into NYC earlier than previously documented and describe the dynamics of seroconversion during the entire course of the first pandemic in a metropolitan area. big market.