PITTSBURGH (KDKA) – With the coronavirus, people can have blood clots all over their body.
This clotting, called thrombosis, can occur in large and small blood vessels, as well as in veins and arteries.
“Thrombotic complications are often related to this disease. Moreso in serious illness but also mild illness. There is clearly a relationship, says Dr. Ashis Tayal, a stroke neurologist at Allegheny Health Network.
Researchers have been trying to find out what’s going on.
“One of the first things we noticed in some patients with severe COVID was these changes in lab studies, which showed changes in normal blood clotting,” said Dr Tayal. of everyone. “
Because some people have been reported to have something called an antiphospholipid antibody, the researchers want to look at this problem in more depth.
“Antiphospholipid antibodies are autoimmune antibodies,”; said Dr. Tayal. “We often diagnose these in people who sometimes suffer from rheumatic diseases, like lupus, as well as cancer and other infections that are also associated with these antiphospholipid antibodies.”
They checked the blood of 172 hospitalized patients with COVID-19, looking for immune system proteins that attacked a person’s body.
“These circulating antibodies can actually interact with normal coagulation mechanisms and may activate our normal clotting mechanism in an abnormal way, and thus induce coagulation,” said Dr Tayal. spontaneous blood clotting.
More than half of patients with the disease and high degree are associated with more blood clotting, more inflammatory cells, more severe lung disease, and poor kidney function.
“I think it’s an important finding because you wouldn’t expect to see a lot of anomalies in the lab in other populations,” said Dr Tayal. “So there’s something unique about COVID that makes these antiphospholipid antibodies and in a much higher percentage of patients you might expect.”
One step to understand why clotting occurs.
“When people were hospitalized for COVID, some were started on anticoagulants to reduce the risk of blood clots,” adds Dr. Tayal.