By Nancy Lapid
(Reuters) – The following is a synthesis of some of the latest scientific studies on the new coronavirus and efforts to find treatments and vaccines for COVID-19, a viral disease.
Conventional cold antibodies provide clues for COVID-19 behavior
Among people who have never been infected with a new coronavirus, some adults – and many children – may have antibodies that can neutralize the virus, the researchers reported Friday in the journal Science. Out of 302 such adults, 16 (5.3%) had antibodies, likely to be produced during a “common cold” coronavirus infection, which reacted with a specific region of mutant protein on the microflora. New draw is referred to as the S2 subunit. Out of 48 children and adolescents, 21 (43.8%) had these antibodies. In test-tube experiments, the blood serum of both younger and elderly people who were not infected with cross-reactive antibodies could neutralize the new coronavirus. That was not the case with sera from study participants lacking these antibodies. “Together, these findings can help explain higher levels of COVID-19 sensitivity in the elderly and provide insight into whether immunity is pre-established to coronavirus according to Does the season provide protection against SARS-CoV-2? The findings also suggest targeting the S2 subunit on the coronavirus’s mutagenic protein may be the basis for a drug or vaccine acting on a wide variety of coronaviruses. (https://bit.ly/3evCSFB)
CT lung accelerates the diagnosis of COVID-19 in stroke patients
In emergency room patients with a stroke, lung imaging studies may help detect COVID-19 before the nose and throat swab test results, the researchers said. Stroke may be a sign of COVID-19, but test results can take days to come. At three hospitals in New York City in March and April, doctors ordered computed tomography angiography (CTA) on 57 stroke patients within 24 hours of admission, to look for pneumonia. related to COVID-19. Thirty patients turned out to have COVID-19, based on their nose picking results. But CTA scan results, combined with patient symptoms like cough and shortness of breath, enable a diagnosis of COVID-19 with 83% accuracy before a cotton swab test result is received. Researchers point out in their report in the American Heart Association’s Stroke journal to screen stroke patients based solely on the symptoms that are unreliable, because they may not have symptoms. or unable to speak. “Early diagnosis through CT has helped our center protect patients and other staff through early isolation, and it also allows us to initiate early supportive care for those who are suspected of being affected. positive stroke for COVID-19 “, co-author Dr Charles Esenwa of the Montefiore Medical Center said in a press release. (https://bit.ly/3pbSCCH)
New coronavirus virus comes out of the cell “with trash”
Researchers have discovered that the new coronavirus uses a surprising pathway to get out of infected cells and continue to infect others. It attacks a cellular structure called the lysosome, usually where cell waste is destroyed. However, the researchers report in the journal Cell said, the virus uses lysosome as an emergency exit. “To my knowledge, coronavirus is one of two or three viruses that can do this and is definitely the only one,” said co-author Nihal Altan-Bonnet of the National Heart, Lung and Blood Institute. , refers to viruses whose genetic material surrounds them. Altan-Bonnet added: “All other coated viruses… use different pathways to spread from cell to cell. These include influenza, hepatitis C, Dengue, Zika, West Nile and Ebola. When the lysosome breaks down bacteria and viruses into small pieces, she explains, “these tiny pieces appear on the cell surface to warn the immune system” of the invaders’ presence. By using the cell’s garbage disposal system to escape, the new coronavirus neutralizes the lysosome and disrupts the immune system’s warning, she said. “We believe that discovering a pathway used by coronaviruses to exit cells will be the basis for us to understand how these viruses are devastating our bodies, especially the immune system. our.” (https://bit.ly/36aBSmr)
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(Reported by Nancy Lapid; Edited by Bill Berkrot)