Reprinted with permission from World At Large, a news website about nature, science, health, politics and travel.
In another study using psychedelic compounds as drugs, two doses of psilocybin – the compound that gives magic to the “magic mushroom” – were found to significantly reduce major depressive symptoms in adult when it is combined with psychotherapy.
Twenty-four adults were included in a small study that included two 5-hour psilocybin sessions and a 24-week follow-up – and the results seemed to shock the researchers at the Psychedelic Research Center and Consciousness (CPCR) at Johns Hopkins School of Medicine.
Alan Davis, Ph.D., professor of psychiatry and behavioral sciences said: “The magnitude of the effects we saw was about four times greater than what the clinical trials showed for drugs. Traditional anti-depressants on the market.
According to the Center for Disease Control (CDC) data, tens of millions of adults have had a chronic anxiety disorder at some point in their lives. About 1in 6 people will experience symptoms of depression at some point in their life.
In this new trial, the researchers looked at whether psilocybin (granted ‘Breakthrough Status’ as a treatment for untreated depression) could be effective enough to be used as a remedy. Treatment for standard depressive disorders or not.
Instead of targeting “reactive” anxiety or depression types – those resulting from traumatic experiences – his team was urged by public health officials to explore the effects of psilocybin in the wider population. for people with long-term, persistent, and less defined major depressive disorders. , because of the potentially greater impact on public health.
Degradation into exclusion
“Because there are several major types of depressive disorder that can lead to a change in the way people respond to treatment, I was surprised when most of our study participants noticed the method. psilocybin is effective, ”said Dr. Roland Griffiths, Director of CPCR and a pioneer in psychotherapy research, who announced his results this week in JAMA Psychiatry.
In the clinical trial, in a group of 24 participants, 67% showed a more than 50% reduction in symptoms of depression at the one-week follow-up and 71% at the four-week follow-up. Overall, four weeks after the treatment, 54% of the participants were considered in remission, meaning they no longer qualified for depression.
The researchers said they would follow the participants for a year after the study to see how long the antidepressant effects of the psilocybin treatment remained and will report their findings in one press. product later.
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“Because most other depression treatments take weeks or months and can have undesirable effects, this could be a game changer if these findings are,” Davis said. for use in future “gold standard” placebo controlled clinical trials.
Becoming more popular
Working at Johns Hopkins since 2003, Roland Griffiths’ psychedelic experiments were first viewed with skepticism, but under his leadership, the CPCR has now completed numerous trials and studies on compounds. hallucinations, such as:
His work led to the US Food and Drug Administration issuing a ‘Breakthrough Therapy’ designation for other compounds as a chemical variant of ketamine, approved in the form of a nasal spray. used to treat depression for veterans in Virginia.
MDMA also earned the title of ‘Breakthrough Therapy’ from the FDA in 2017, after research demonstrated its “amazing” success in delivering PTSD in remission.
Meanwhile, its status is illegal The drug is changing. On Tuesday, Oregon voters passed a first to formally legalize access to psilocybin mushrooms, with the state establishing and modifying a program by which adults can take and use them. And, voters in Washington DC have passed a measure that will effectively de-identify “magic mushrooms” and other organic psychedelic drugs.
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